Let me start off by saying that I am not that excited about UFC 100. I think the card should have at least one more title fight on it. I guess I can blame BJ Penn for taking too long between fights, but I would like to have seen the BJ/Florian fight added to the card.
Lesnar/Mir - I care least about the Heavyweights than any other division, whether UFC or not, and both of these guys come off as dicks in the media and that doesn't help. I know Mir beat Brock once, but I think Brock has learned enough submission defense in the last year to last long enough to land 1 or 2 big punches to Franks dome. I could probably outbox an 8-year-old, but I wouldn't want to fight one that had cinder blocks for fists. I pick Lesnar by 2nd round KO.
GSP/Alves - I don't buy all the hype about GSP. He's beaten an older Hughes (so has Alves), been beaten by Serra, and he's beaten Koschek (so has Alves) who I haven't been 100% impressed by. His win against Fitch was great though. His win against BJ was dominating, but he beat up a lightweight and BJ should have never wanted that fight. I know Alves lost to Fitch, but that was 3 years ago. GSP is great, and many rank him as a top pound for pound guy, but I'm picking Alves in this one. He's just a beast who will probably be able to outmuscle GSP and keep the fight standing. I see this as sort of a Mike Brown/Uriah Faber fight where Faber/GSP may be more well rounded but Brown/Alves are just monsters in their weight classes.
Henderson/Bisbing - I don't see either of these guys beating Maia, Marquart or Anderson Silva, so I think this fight will have no serious repurcussions. Yeah they think they will get a title shot if they win, but they have to get in line behind those other two if you ask me, and with Wanderlei moving down, the title picture gets even murkier. I'll pick Bisbing in an upset though.
Note: I don't see Wanderlei beating any of those top two or 3 guys either.
Fitch/Thiago - Fitch wins by crazy beard.
Akiyama/Belcher - I don't really know much about either guy.
Bonnar/Coleman - Bonnar wins by not being old.